Increased circulating levels of angiotensin-(1–7) in severely ill COVID-19 patients
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SciScore for 10.1101/2021.02.01.20232785: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study protocol has been approved by the Ethics Committee of the Federal University of Minas Gerais, Belo Horizonte, Brazil (CAAE 34080720.0.1001.5149). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Finally, with all the limitations of the small cohort included in this study, …
SciScore for 10.1101/2021.02.01.20232785: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study protocol has been approved by the Ethics Committee of the Federal University of Minas Gerais, Belo Horizonte, Brazil (CAAE 34080720.0.1001.5149). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Finally, with all the limitations of the small cohort included in this study, this is the first report of the direct measurement of RAS peptides in the circulation of COVID-19 patients. Although future studies are obviously necessary to better understand the effects of this disease on RAS pathways, our data provide new insights for the interpretation and planning of future therapies to modulate the RAS in the context of COVID-19.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04633772 Recruiting Use of Angiotensin-(1-7) in COVID-19 NCT04332666 Not yet recruiting Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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