Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
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SciScore for 10.1101/2020.05.08.084996: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Human Olfactory and Nasal Tissue: The research protocol involving human specimens was approved by the Johns Hopkins institutional review board, and all subjects provided signed informed consent.
Consent: Human Olfactory and Nasal Tissue: The research protocol involving human specimens was approved by the Johns Hopkins institutional review board, and all subjects provided signed informed consent.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources The following primary antibodies were used: Goat anti-ACE2 (1:40, AF933; R&D) Mouse anti-Keratin 18 (1:500, … SciScore for 10.1101/2020.05.08.084996: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Human Olfactory and Nasal Tissue: The research protocol involving human specimens was approved by the Johns Hopkins institutional review board, and all subjects provided signed informed consent.
Consent: Human Olfactory and Nasal Tissue: The research protocol involving human specimens was approved by the Johns Hopkins institutional review board, and all subjects provided signed informed consent.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources The following primary antibodies were used: Goat anti-ACE2 (1:40, AF933; R&D) Mouse anti-Keratin 18 (1:500, Pierce MA1-39483) anti-ACE2suggested: Noneanti-Keratin 18suggested: ( Cat# 21306, RRID:AB_895598), Rabbit anti-DCX (1:500, GeneTex, GTX134052) anti-DCXsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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