Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
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SciScore for 10.1101/2021.03.07.21252875: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Ancestry was inferred by performing projection onto the principal component analysis (PCA) space from the 1000G17 Phase 3 population using HapMap3 SNPs18 with minor allele frequency > 1% (detailed methods are in the online supplement) (Supplementary Table 1, Supplementary Figure 1). HapMap3suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from Li…SciScore for 10.1101/2021.03.07.21252875: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Ancestry was inferred by performing projection onto the principal component analysis (PCA) space from the 1000G17 Phase 3 population using HapMap3 SNPs18 with minor allele frequency > 1% (detailed methods are in the online supplement) (Supplementary Table 1, Supplementary Figure 1). HapMap3suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has important limitations. Each cohort has its own selection bias and ascertainment bias. Several studies were enriched for severe patients, whereas UKB is a non-COVID-19 cohort, with evidence of healthy volunteer bias35. Nevertheless, it may be less prone to selection bias than the COVID-19 cohorts. Selection bias is inherent to most COVID-19 observational studies36 and this influences the generalizability of the results outside the study populations. To mitigate against these potential issues, we combined data from observational studies with different ascertainment strategies, including national healthcare systems, studies that were established prior to the COVID-19 pandemic and thus recruitment was not dependent upon COVID-19 status and hospital-based studies. This allowed for an increased representation of individuals with severe COVID-19 outcomes. We also provide analyses restricted to hospitalized patients, which is an ascertained, but clinically-relevant population. While we included information from participants who were of non-European ancestry, on-going efforts should enable larger sample sizes in these ancestries to better define the importance of the chromosome 3 risk locus in these contexts. This further emphasizes the importance of developing genomics-enabled studies in individuals of non-European ancestry. In summary, the major genetic COVID-19 risk locus is common and has large effects on COVID-19 outcomes including mortality. These effects are age-...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
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- Thank you for including a protocol registration statement.
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