Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern
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SciScore for 10.1101/2021.03.16.21253716: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Blood sample collection: Blood samples were collected following a protocol (study number: 116284) approved by the Research Ethics Board (REB) of Western University. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Slides were then rinsed quickly three times followed by three 5min washes with TBST before probing with goat anti-human IgG HRP antibody at 1:10,000 (Millipore Sigma) in ChonBlock for 1h. anti-human IgGsuggested: NoneSoftware and Algorithms Sentences Resources Array Quantification: Peptide walking arrays, literature-reported epitope peptide … SciScore for 10.1101/2021.03.16.21253716: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Blood sample collection: Blood samples were collected following a protocol (study number: 116284) approved by the Research Ethics Board (REB) of Western University. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Slides were then rinsed quickly three times followed by three 5min washes with TBST before probing with goat anti-human IgG HRP antibody at 1:10,000 (Millipore Sigma) in ChonBlock for 1h. anti-human IgGsuggested: NoneSoftware and Algorithms Sentences Resources Array Quantification: Peptide walking arrays, literature-reported epitope peptide arrays and the master epitope arrays were quantified using ImageJ software(42). ImageJsuggested: (ImageJ, RRID:SCR_003070)Statistical analysis: All statistical analyses were done using the GraphPad Prism9 software. GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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