Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection
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SciScore for 10.1101/2021.01.31.21250870: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Subject Enrollment: The studies were approved by the institutional review boards of Yale University (#2000027792 and #1401013259) and Duke University (Pro00105518 and Pro00106151).
Consent: Written informed consent was provided by all subjects prior to study activities.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Differences between groups were analyzed by Kruskal-Wallis test with Benjamini-Hochberg post-hoc test to control for false discovery rate or one-way ANOVA with Fisher’s LSD post-hoc test (Graphpad Prism, San Diego, CA). Gr…SciScore for 10.1101/2021.01.31.21250870: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Subject Enrollment: The studies were approved by the institutional review boards of Yale University (#2000027792 and #1401013259) and Duke University (Pro00105518 and Pro00106151).
Consent: Written informed consent was provided by all subjects prior to study activities.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Differences between groups were analyzed by Kruskal-Wallis test with Benjamini-Hochberg post-hoc test to control for false discovery rate or one-way ANOVA with Fisher’s LSD post-hoc test (Graphpad Prism, San Diego, CA). Graphpadsuggested: (GraphPad, RRID:SCR_000306)Simple linear regression were performed by Prism. Prismsuggested: (PRISM, RRID:SCR_005375)Partial least-squares discriminant analysis (PLS-DA) was performed using SIMCA v15 (Umetrics, Umeå, Sweden). SIMCAsuggested: (SIMCA, RRID:SCR_014688)The random-forest feature selection (Boruta algorithm) was performed using the Boruta package in R software. Borutasuggested: (Boruta, RRID:SCR_016234)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First, we only recruited subjects that had ongoing symptoms after COVID-19 infection, therefore we cannot report the true prevalence of symptoms or pulmonary function derangements in subjects with asymptomatic infection or in subjects with symptom resolution after COVID-19 infection. Second, our plasma biomarker profiles represent a single time point for each subject, and therefore we cannot draw conclusions about trajectory or changes over time. Third, we cannot establish mechanism in this human cohort study; however, our findings are highly associational and lay the foundations to drive further work in this area. In conclusion, persistent respiratory symptoms and impaired lung function are common after acute COVID-19 illness, but subjective symptoms alone do not predict lung injury. Partial least-squares discriminant analysis reliably identifies and separates subjects by COVID-19 illness severity based on their plasma biomarker profiles, even 9 weeks after recovery. Circulating factors associated with acute neutrophil activation, fibrosis signaling, and alveolar epithelial repair remain elevated in survivors of acute COVID-19 infection and strongly associate with impaired pulmonary function. Our study provides novel insights into divergent host responses of lung repair after COVID-19 pneumonia and suggest that immunologic and fibrotic drivers of disease severity in the acute COVID-19 illness may regulate the trajectory of recovery in the p...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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