A MUC 5 B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality
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SciScore for 10.1101/2021.09.28.21263911: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: All protocols were approved by the VA Central Institutional Review Board and all participants provided written informed consent.
Consent: All protocols were approved by the VA Central Institutional Review Board and all participants provided written informed consent.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:S…
SciScore for 10.1101/2021.09.28.21263911: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: All protocols were approved by the VA Central Institutional Review Board and all participants provided written informed consent.
Consent: All protocols were approved by the VA Central Institutional Review Board and all participants provided written informed consent.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Strengths & Limitations: MVP is a large genomic medicine database with diverse ethnicity and geography. MVP participants are predominantly males but it represents a large multi-ethnic, prospective cohort available. Successful replication in the HGI and meta-analysis is a strength as well as our ability to investigate specific clinical events post-index. PheWAS was designed as a broad screen to test for potentially clinically relevant associations between genes and phenotypes and helped in the understanding of potential disease mechanisms but has limited power to detect associations among uncommon conditions, especially when further stratified by genetic ancestry.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
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