Tissue-Specific Immunopathology in Fatal COVID-19
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Abstract
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SciScore for 10.1101/2020.07.02.20145003: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable The patients had a mean age of 77 years (range 64–97), 10/11 were male, and four received invasive mechanical ventilation during their hospital admission. Table 2: Resources
Antibodies Sentences Resources For immunophenotyping, multiplexed immunofluorescence on de-paraffinised rehydrated FFPE slides was performed using combinations of primary antibodies against CD34, CD68, MRP8, CD4, CD8 and CD20, labelled with TSA-conjugated fluorophores, with antibody removal between steps. CD34suggested: NoneCD68suggested: NoneMRP8suggested: NoneCD4suggested: NoneCD8s…SciScore for 10.1101/2020.07.02.20145003: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable The patients had a mean age of 77 years (range 64–97), 10/11 were male, and four received invasive mechanical ventilation during their hospital admission. Table 2: Resources
Antibodies Sentences Resources For immunophenotyping, multiplexed immunofluorescence on de-paraffinised rehydrated FFPE slides was performed using combinations of primary antibodies against CD34, CD68, MRP8, CD4, CD8 and CD20, labelled with TSA-conjugated fluorophores, with antibody removal between steps. CD34suggested: NoneCD68suggested: NoneMRP8suggested: NoneCD4suggested: NoneCD8suggested: NoneCD20suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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