COVID-19 Myocardial Pathology Evaluation in Athletes With Cardiac Magnetic Resonance (COMPETE CMR)
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SciScore for 10.1101/2020.08.31.20185140: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the institutional review board at Vanderbilt University Medical Center. Randomization not detected. Blinding CMR post-processing: CMR post-processing was performed blinded to clinical data. Power Analysis not detected. Sex as a biological variable Our laboratory’s normal values for parametric mapping are derived from a cohort of 54 healthy controls of varying age (range 7-56 years old) and gender (N=29 male) prospectively enrolled and then broken down into the appropriate gender and age (>18 y/o and <18 y/o) category for comparison. Table 2: Resources
Software and Algorithms Sentences Resources Clinical demographics, laboratory, … SciScore for 10.1101/2020.08.31.20185140: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the institutional review board at Vanderbilt University Medical Center. Randomization not detected. Blinding CMR post-processing: CMR post-processing was performed blinded to clinical data. Power Analysis not detected. Sex as a biological variable Our laboratory’s normal values for parametric mapping are derived from a cohort of 54 healthy controls of varying age (range 7-56 years old) and gender (N=29 male) prospectively enrolled and then broken down into the appropriate gender and age (>18 y/o and <18 y/o) category for comparison. Table 2: Resources
Software and Algorithms Sentences Resources Clinical demographics, laboratory, electrocardiographic, and CMR results were stored in the REDCap electronic platform.(8) Healthy controls were used from a cohort of healthy adult subjects over 18 years old who had previously consented for non-contrasted CMR imaging, including parametric mapping; these controls were a subset of the subjects used to derive our laboratory’s normal control values. REDCapsuggested: (REDCap, RRID:SCR_003445)Statistical analysis was performed using STATA, version 15 (StatCorp LLC, College Station, TX) software. STATAsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: There are inherent limitations of the retrospective design of this study. First, clinical outcomes among the collegiate athletes with and without CMR findings are not yet available. While COVID-19+ athletes were mandated to have laboratory, electrocardiographic, echocardiographic, and CMR imaging performed prior to return to sports participation, CMR was prioritized and some of this testing is incomplete at the current time. Baseline athletic performance phenotyping (quantification of baseline aerobic and strength training activities per week, peak VO2 with cardiopulmonary exercise testing, etc.) was not studied. While our cohorts’ diversity of sports and size limits our ability to determine if the type or aerobic intensity of sport affects the implications of the cardiovascular sequelae following COVID-19 infection, CMR volumetrics of our cohort point towards athlete’s heart (increased LV mass and increased four-chamber volumes), which as generalizability to many US competitive athletes. Our study did not enroll children < 18 years old, and therefore caution should be taken with generalization of these results to that age group.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 24. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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