Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia
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Although male mice experience greater relative body weight losses, similar skeletal muscle and adipose tissue wasting occurs between male and female mice in the Kras LSL-G12D , Ptf1a Cre-ER/+ , Pten flox/flox (KPP) model of pancreatic-cancer-induced cachexia. Greater weight loss in males may be related to longer survival. However, differences in tamoxifen dose relative to body weight may have accelerated tumor formation in female mice and, therefore, may be a relevant consideration for inducible tumor models.
