Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
We aimed to investigate demographic, lifestyle, socioeconomic and clinical risk factors for COVID-19, and compared them to risk factors for pneumonia and influenza in UK Biobank.
Design
Cohort study.
Setting
UK Biobank.
Participants
49–83 year olds (in 2020) from a general population study.
Main outcome measures
Confirmed COVID-19 infection (positive SARS-CoV-2 test). Incident influenza and pneumonia were obtained from primary care data. Poisson regression was used to study the association of exposure variables with outcomes.
Results
Among 235 928 participants, 397 had confirmed COVID-19. After multivariable adjustment, modifiable risk factors were higher body mass index and higher glycated haemoglobin (HbA1C) (RR 1.28 and RR 1.14 per SD increase, respectively), smoking (RR 1.39), slow walking pace as a proxy for physical fitness (RR 1.53), and use of blood pressure medications as a proxy for hypertension (RR 1.33). Higher forced expiratory volume in 1 s (FEV1) and high-density lipoprotein (HDL) cholesterol were both associated with lower risk (RR 0.84 and RR 0.83 per SD increase, respectively). Non-modifiable risk factors included male sex (RR 1.72), black ethnicity (RR 2.00), socioeconomic deprivation (RR 1.17 per SD increase in Townsend Index), and high cystatin C (RR 1.13 per SD increase). The risk factors overlapped with pneumonia somewhat, less so for influenza. The associations with modifiable risk factors were generally stronger for COVID-19, than pneumonia or influenza.
Conclusion
These findings suggest that modification of lifestyle may help to reduce the risk of COVID-19 and could be a useful adjunct to other interventions, such as social distancing and shielding of high risk.
Article activity feed
-
-
SciScore for 10.1101/2020.04.28.20083295: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: 12,13 UK Biobank received ethical approval from the North West Multi-Centre Research Ethics Committee (REC reference: 11/NW/03820).
Consent: All participants gave written informed consent before enrolment in the study, which was conducted in accord with the principles of the Declaration of Helsinki.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Further details of these measurements can be found in the UK Biobank Data Showcase and Protocol (http://www.ukbiobank.ac.uk). http://www.ukbiobank.ac.uksuggested: (UK Biobank, RRID:SCR_012815)SciScore for 10.1101/2020.04.28.20083295: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: 12,13 UK Biobank received ethical approval from the North West Multi-Centre Research Ethics Committee (REC reference: 11/NW/03820).
Consent: All participants gave written informed consent before enrolment in the study, which was conducted in accord with the principles of the Declaration of Helsinki.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Further details of these measurements can be found in the UK Biobank Data Showcase and Protocol (http://www.ukbiobank.ac.uk). http://www.ukbiobank.ac.uksuggested: (UK Biobank, RRID:SCR_012815)Analyses were conducted in R Statistical Software version 3.5.3 with the package “mgcv”. R Statisticalsuggested: (R Project for Statistical Computing, RRID:SCR_001905)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations include that UK Biobank is not representative of the whole UK population,35 (our data focuses on England specifically) although this is generally not a concern in investigating risk associations36. Care should be taken in generalising the PAF estimates. These related to cases occurring within the UK Biobank population, but are not directly applicable to the general population where the prevalence of risk factors is different. However, they allowed a direct comparison between COVID-19 and pneumonia in the same cohort. Due to the under-representation of non-white ethnicities in UK Biobank, we have limited power to explore important interactions by ethnic group (although Black ethnicity was associated with the outcome), and we recognise this as an important risk factor. Ascertainment bias, including differential healthcare seeking, differential testing and differential prognosis may explain some differences in outcomes given poor coverage of testing in the UK. It is also likely that cases will generally be at the more severe end of the clinical spectrum by using hospitalised cases as the outcome, although use of admission to ITU would be additionally informative once sufficient case numbers accrue. Despite this, we still observe many similar risk factors to incident pneumonia, which is more likely to have close to complete case ascertainment in primary care records, although, as discussed, other risk factors seem more strongly linked to COVID-19 infections. Exposures...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-