Severity of maternal SARS-CoV-2 infection and perinatal outcomes of women admitted to hospital during the omicron variant dominant period using UK Obstetric Surveillance System data: prospective, national cohort study

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1. Version published to 10.1136/bmjmed-2022-000190

   Aug 1, 2022
2. 

   ScreenIT

   Mar 12, 2022

   SciScore for 10.1101/2022.03.07.22271699: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	13 Information on women who died, or who had stillbirths or neonatal deaths, was cross-checked with data from the organisation responsible for maternal and perinatal death surveillance in the UK (MBRRACE-UK).
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	In this national observational study, the study sample size was governed by the disease incidence, thus no formal power calculation was carried out.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Statistical analyses were performed using STATA version 17 (Statacorp, TX, USA).	STATA suggested: (Stata, RRID:SCR_012763) Statacorp suggested: None

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   Results from OddPub: We did not …

   SciScore for 10.1101/2022.03.07.22271699: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	13 Information on women who died, or who had stillbirths or neonatal deaths, was cross-checked with data from the organisation responsible for maternal and perinatal death surveillance in the UK (MBRRACE-UK).
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	In this national observational study, the study sample size was governed by the disease incidence, thus no formal power calculation was carried out.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Statistical analyses were performed using STATA version 17 (Statacorp, TX, USA).	STATA suggested: (Stata, RRID:SCR_012763) Statacorp suggested: None

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   Strengths and weaknesses of the study: To our knowledge, this is the first national prospective cohort study to describe pregnancy and perinatal outcomes during the period when the Omicron SARS-CoV-2 variant was dominant. A key strength of these data is the existing mechanism for national case identification of all women admitted to hospital across the UK, and therefore the low risk of selection bias. In the UK, universal SARS-CoV-2 testing for all obstetric admissions was implemented from May 2020. Asymptomatic pregnant women in whom SARS-CoV-2 infection is detected by screening on admission, are most commonly admitted to give birth.17 We therefore categorised the included women by cause of admission or symptoms to avoid misclassification bias and increased adverse outcomes being incorrectly attributed to SARS-CoV-2.18 Some of the pregnant women who had received two vaccine doses or fewer may also have delayed the second dose due to covid-19 infection; information about previous infection was not available in the current study. These women could potentially be misclassified into a category with lower expected protection while having reduced risk due to post-infection immunity, and this could result in overestimation of the protective effect of different vaccine doses. As with previous analyses,5 variant sequencing data were not available for individual women, and a proxy time period was used instead which may be considered a limitation. Additionally, more women in the sympto...

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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3. 

   Version published to 10.1101/2022.03.07.22271699 on medRxiv

   Mar 9, 2022