Performance of Three Tests for SARS-CoV-2 on a University Campus Estimated Jointly with Bayesian Latent Class Modeling
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Abstract
Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been vitally important during the COVID-19 pandemic. There are a variety of methods for testing for this virus, and it is important to understand their accuracy in choosing which one might be best suited for a given application.
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SciScore for 10.1101/2021.07.31.21261425: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Another limitation of our study is that the only information we used to resolve uncertainty about true infection status was whether individuals were tested for surveillance purposes. Given that prevalence differed by an order of magnitude between these groups, this was quite beneficial. However, additional information—such as recent contacts or status as …
SciScore for 10.1101/2021.07.31.21261425: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Another limitation of our study is that the only information we used to resolve uncertainty about true infection status was whether individuals were tested for surveillance purposes. Given that prevalence differed by an order of magnitude between these groups, this was quite beneficial. However, additional information—such as recent contacts or status as student, faculty or staff—could have potentially helped narrow this type of uncertainty further. Doing so would have required estimating more parameters and could have made the analysis more susceptible to bias if an increasingly complex model were not specified properly. In addition to limitations of our analysis, there were also limitations of our data set. First, a more balanced testing effort across different test types and groups of subjects could have helped reduce uncertainty about certain parameters, especially those relating to antigen tests. Second, for individuals who truly were positive, we have no information about how many days elapsed between their initial exposure and when they were tested. Given how variable test sensitivity is over the course of an infection (11, 17), this factor alone could be a major driver of the sensitivities we estimated. For example, individuals tested for surveillance screening had presumably not displayed any symptoms up to the time of testing, making it possible that many of our positive surveillance tests came from presymptomatic individuals with high viral loads (36). Even so, the...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 20. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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