Spike Protein Antibodies Mediate the Apparent Correlation between SARS-CoV-2 Nucleocapsid Antibodies and Neutralization Test Results

  1. Thomas Perkmann
  2. Thomas Koller
  3. Nicole Perkmann-Nagele
  4. Miriam Klausberger
  5. Mark Duerkop
  6. Barbara Holzer
  7. Boris Hartmann
  8. Patrick Mucher
  9. Astrid Radakovics
  10. Maria Ozsvar-Kozma
  11. Oswald F. Wagner
  12. Christoph J. Binder
  13. Helmuth Haslacher

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Abstract

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  1. Version published to 10.1128/spectrum.00218-21
  2. ScreenIT

    SciScore for 10.1101/2021.04.08.21255143: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Samples were either left-over materials from the General Hospital Vienna or donated by convalescent donors giving written informed consent (EK 2011/404).
    IRB: This evaluation is part of a study which was reviewed and approved by the ethics committee of the Medical University of Vienna (EK 2257/2020).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    To test whether a correlation is disturbed by a mediator (e.g. RBD or S1/S2 antibody concentrations), partial rank correlation tests and mediation analyses, according to Hayes (11) were performed.
    S1/S2
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.04.08.21255143 on medRxiv