Vaccinating Children against COVID-19: Commentary and Mathematical Modeling
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Abstract
Countries have recently begun implementation of childhood vaccination against SARS-CoV-2 with the Pfizer/BioNTech mRNA vaccine in children 5 to 11 years of age. Because SARS-CoV-2 disease severity is remarkably age dependent, vaccinating children may have modest public health benefits, relative to the unequivocal benefit of vaccinating vulnerable older adults.
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SciScore for 10.1101/2022.01.05.22268820: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our modelling study has several limitations. The model was based on a deterministic compartmental SIR model; thus, stochastic effects were not considered.10 The system of 49 ODEs was parameterized with vital statistics from Australia or Alberta; therefore, extrapolation to other regions should be done with caution. On the other hand, the …
SciScore for 10.1101/2022.01.05.22268820: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our modelling study has several limitations. The model was based on a deterministic compartmental SIR model; thus, stochastic effects were not considered.10 The system of 49 ODEs was parameterized with vital statistics from Australia or Alberta; therefore, extrapolation to other regions should be done with caution. On the other hand, the age structure and age-specific mortality rates were similar to other high-income, urbanized settings. Age-assortative mixing was incorporated into the model using social contact matrices; however, these were based on pre-pandemic surveys.9 Other investigators have demonstrated changes in contact rate with evolution of the pandemic, and have considered context-specific changes in contact rates (e.g. school closures).20,21 We used a composite ‘social distancing’ index (θ) to capture the combined effects of physical isolation, face masks, improved hand hygiene on the contact rate.8 This represents a simplification but is justified in the absence of data on the efficacy and uptake of various public health interventions in different age groups. The duration of infection prior to death or recovery was assumed to follow an exponential distribution. Recovered individuals in our model were considered immune (removed permanently from the susceptible pool); we did not incorporate waning immunity in the model. More complex mathematical formulations would be needed to reflect alternative distributions of the duration of infection and immunity. The co-circ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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