Guild-Level Microbiome Signature Associated with COVID-19 Severity and Prognosis

  1. Mingquan Guo
  2. Guojun Wu
  3. Yun Tan
  4. Yan Li
  5. Xin Jin
  6. Weiqiang Qi
  7. Xiaokui Guo
  8. Chenhong Zhang
  9. Zhaoqin Zhu
  10. Liping Zhao

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Abstract

Previous reports on the associations between COVID-19 and gut microbiome have been constrained by taxonomic-level analysis and overlook the interaction between microbes. By applying a genome-resolved, reference-free, guild-based metagenomic analysis, we demonstrated that the relationship between gut microbiota and COVID-19 is genome-specific instead of taxon-specific or even species-specific.

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  1. Version published to 10.1128/mbio.03519-22
  2. Rapid Reviews Infectious Diseases

    Teresa Nogueira

    Review 2: "Guild-level microbiome signature associated with COVID-19 severity and prognosis"

    This study identifies microbial guilds associated with mild or severe cases of COVID-19, and uses ML to predict the clinical outcome of SARS-COV-2 infection in other cohorts based on the 2 guilds. Reviewers encourage decision-makers to consider the claims potentially actionable.

  3. Rapid Reviews Infectious Diseases

    Olaf Larsen

    Review 1: "Guild-level microbiome signature associated with COVID-19 severity and prognosis"

    This study identifies microbial guilds associated with mild or severe cases of COVID-19, and uses ML to predict the clinical outcome of SARS-COV-2 infection in other cohorts based on the 2 guilds. Reviewers encourage decision-makers to consider the claims potentially actionable.

  5. Version published to 10.1101/2022.09.18.508418v1 on bioRxiv