Guild-Level Microbiome Signature Associated with COVID-19 Severity and Prognosis
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Abstract
Previous reports on the associations between COVID-19 and gut microbiome have been constrained by taxonomic-level analysis and overlook the interaction between microbes. By applying a genome-resolved, reference-free, guild-based metagenomic analysis, we demonstrated that the relationship between gut microbiota and COVID-19 is genome-specific instead of taxon-specific or even species-specific.
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Teresa Nogueira
Review 2: "Guild-level microbiome signature associated with COVID-19 severity and prognosis"
This study identifies microbial guilds associated with mild or severe cases of COVID-19, and uses ML to predict the clinical outcome of SARS-COV-2 infection in other cohorts based on the 2 guilds. Reviewers encourage decision-makers to consider the claims potentially actionable.
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Olaf Larsen
Review 1: "Guild-level microbiome signature associated with COVID-19 severity and prognosis"
This study identifies microbial guilds associated with mild or severe cases of COVID-19, and uses ML to predict the clinical outcome of SARS-COV-2 infection in other cohorts based on the 2 guilds. Reviewers encourage decision-makers to consider the claims potentially actionable.
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Strength of evidence
Reviewers: Olaf Larsen (Vrije University) | 📘📘📘📘📘
Teresa Nogueira (INIAV) | 📗📗📗📗◻️ -
