The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

  1. Bryan E. Jones
  2. Patricia L. Brown-Augsburger
  3. Kizzmekia S. Corbett
  4. Kathryn Westendorf
  5. Julian Davies
  6. Thomas P. Cujec
  7. Christopher M. Wiethoff
  8. Jamie L. Blackbourne
  9. Beverly A. Heinz
  10. Denisa Foster
  11. Richard E. Higgs
  12. Deepa Balasubramaniam
  13. Lingshu Wang
  14. Yi Zhang
  15. Eun Sung Yang
  16. Roza Bidshahri
  17. Lucas Kraft
  18. Yuri Hwang
  19. Stefanie Žentelis
  20. Kevin R. Jepson
  21. Rodrigo Goya
  22. Maia A. Smith
  23. David W. Collins
  24. Samuel J. Hinshaw
  25. Sean A. Tycho
  26. Davide Pellacani
  27. Ping Xiang
  28. Krithika Muthuraman
  29. Solmaz Sobhanifar
  30. Marissa H. Piper
  31. Franz J. Triana
  32. Jorg Hendle
  33. Anna Pustilnik
  34. Andrew C. Adams
  35. Shawn J. Berens
  36. Ralph S. Baric
  37. David R. Martinez
  38. Robert W. Cross
  39. Thomas W. Geisbert
  40. Viktoriya Borisevich
  41. Olubukola Abiona
  42. Hayley M. Belli
  43. Maren de Vries
  44. Adil Mohamed
  45. Meike Dittmann
  46. Marie I. Samanovic
  47. Mark J. Mulligan
  48. Jory A. Goldsmith
  49. Ching-Lin Hsieh
  50. Nicole V. Johnson
  51. Daniel Wrapp
  52. Jason S. McLellan
  53. Bryan C. Barnhart
  54. Barney S. Graham
  55. John R. Mascola
  56. Carl L. Hansen
  57. Ester Falconer

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Abstract

LY-CoV555, a SARS-CoV-2 spike protein–specific antibody, neutralizes SARS-CoV-2 and protects the airways of nonhuman primates against infection.

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  1. Version published to 10.1126/scitranslmed.abf1906
  2. Version published to 10.1101/2020.09.30.318972v3 on bioRxiv
  3. Version published to 10.1101/2020.09.30.318972v2 on bioRxiv
  4. ScreenIT

    SciScore for 10.1101/2020.09.30.318972: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04411628CompletedA Study of LY3819253 (LY-CoV555) in Participants Hospitalize…
    NCT04427501RecruitingA Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) i…
    NCT04427501RecruitingA Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) i…
    NCT04497987RecruitingA Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) i…
    NCT04501978RecruitingACTIV-3: Therapeutics for Inpatients With COVID-19

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  5. Version published to 10.1101/2020.09.30.318972v1 on bioRxiv