Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
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Abstract
MIS-C is defined by lymphocyte activation, including elevated plasmablast frequencies and marked activation of CX3CR1 + CD8 + T cells.
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SciScore for 10.1101/2020.09.25.20201863: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All participants or their surrogates provided informed consent in accordance with protocols approved by the regional ethical research boards and the Declaration of Helsinki. Blood Processing: Peripheral blood was collected into sodium heparin tubes (BD, Cat#367874) and processed for staining from whole blood or for PBMC, as previously described 22,25. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Human Subjects: Clinical data abstraction: For inpatients, clinical data were abstracted from the electronic medical record into … SciScore for 10.1101/2020.09.25.20201863: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All participants or their surrogates provided informed consent in accordance with protocols approved by the regional ethical research boards and the Declaration of Helsinki. Blood Processing: Peripheral blood was collected into sodium heparin tubes (BD, Cat#367874) and processed for staining from whole blood or for PBMC, as previously described 22,25. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Human Subjects: Clinical data abstraction: For inpatients, clinical data were abstracted from the electronic medical record into REDCap databases. REDCapsuggested: (REDCap, RRID:SCR_003445)Flow Cytometric Analyses: All analysis and visualization was performed in FlowJo (Treestar, version 10.6.2). FlowJosuggested: (FlowJo, RRID:SCR_008520)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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