The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

  1. Lakshmanane Premkumar
  2. Bruno Segovia-Chumbez
  3. Ramesh Jadi
  4. David R. Martinez
  5. Rajendra Raut
  6. Alena J. Markmann
  7. Caleb Cornaby
  8. Luther Bartelt
  9. Susan Weiss
  10. Yara Park
  11. Caitlin E. Edwards
  12. Eric Weimer
  13. Erin M. Scherer
  14. Nadine Rouphael
  15. Srilatha Edupuganti
  16. Daniela Weiskopf
  17. Longping V. Tse
  18. Yixuan J. Hou
  19. David Margolis
  20. Alessandro Sette
  21. Matthew H. Collins
  22. John Schmitz
  23. Ralph S. Baric
  24. Aravinda M. de Silva

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Abstract

The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance.

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  1. Version published to 10.1126/sciimmunol.abc8413
  2. ScreenIT

    SciScore for 10.1101/2020.05.06.20093377: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).

    Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 18. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.05.06.20093377 on medRxiv