Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

  1. Fan Yang
  2. Sandra C. A. Nielsen
  3. Ramona A. Hoh
  4. Katharina Röltgen
  5. Oliver Fabian Wirz
  6. Emily Haraguchi
  7. Grace H. Jean
  8. Ji-Yeun Lee
  9. Tho D. Pham
  10. Katherine J. L. Jackson
  11. Krishna M. Roskin
  12. Yi Liu
  13. Khoa Nguyen
  14. Robert S. Ohgami
  15. Eleanor M. Osborne
  16. Kari C. Nadeau
  17. Claus U. Niemann
  18. Julie Parsonnet
  19. Scott D. Boyd

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Abstract

It remains unclear whether B cell repertoires against coronaviruses and other pathogens differ between adults and children and how important these distinctions are. Yang et al. analyzed blood samples from young children and adults, as well as tissues from deceased organ donors, characterizing the B cell receptor (BCR) repertoires specific to six common pathogens and two viruses that they had not seen before: Ebola virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children had higher frequencies of B cells with convergent BCR heavy chains against previously encountered pathogens and higher frequencies of class-switched convergent B cell clones against SARS-CoV-2 and related coronaviruses. These findings suggest that encounters with coronaviruses in early life may produce cross-reactive memory B cell populations that contribute to divergent COVID-19 susceptibilities.

Science , this issue p. 738

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  1. Version published to 10.1126/science.abf6648
  2. ScreenIT

    SciScore for 10.1101/2020.12.01.407015: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The IGH repertoire data for the deceased organ donors and the cord blood infant samples is in BioProject: PRJNA674610.
    BioProject
    suggested: (NCBI BioProject, RRID:SCR_004801)

    Results from OddPub: Thank you for sharing your data.

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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  3. Version published to 10.1101/2020.12.01.407015v1 on bioRxiv