Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic

  1. Marta Fernandez‐Fuertes
  2. Anaïs Corma‐Gomez
  3. Eva Torres
  4. Elena Rodriguez‐Pineda
  5. Ana Fuentes‐Lopez
  6. Pilar Rincon
  7. Nieves Fernandez
  8. Federico Garcia
  9. Samuel Bernal
  10. Luis M. Real
  11. Juan Macias
  12. Juan A. Pineda

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Abstract

No abstract available

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  1. Version published to 10.1111/tbed.14293
  2. ScreenIT

    SciScore for 10.1101/2021.03.20.21253397: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The Ethics committee of the Hospital Universitario Virgen de Valme approved the study.
    Consent: All patients gave written informed consent to be entered in the cohort.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    SARS-CoV-2 infection diagnosis: A diagnosis of SARS-CoV-2 infection was established if, at least, one of the following criteria were met: 1) SARS-CoV-2 RNA or antigen was detected in nasopharynx exudate by PCR or immunochromatography, respectively; 2) Seroconversion for SARS-CoV-2 antibodies was documented between the baseline (pre-pandemic) and the follow-up (intra-pandemic) samples.
    SARS-CoV-2
    suggested: None
    Software and Algorithms
    SentencesResources
    These analyses were carried out using IBM SPSS 25.0 (IBM Corporation) and STATA 12.0 (StataCorp).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)
    STATA
    suggested: (Stata, RRID:SCR_012763)
    StataCorp
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This work may have some limitations. First, incidence comparisons were not age nor sex-standardized. PLWH from this cohort are relatively younger, could bear less comorbidities than the general population and includes a higher proportion of males. Nevertheless, the analysis of factors associated with incident SARS-Cov-2 infection did not show the risk of infection varied according to sex or Charlson index, which includes age and comorbidities. Second, the study results are applicable to settings where most patients are under effective antiretroviral therapy, with HIV replication suppression and high CD4 cell counts. The present study conclusions may not be valid for PLWH in advanced or untreated HIV infection. As a counterpart, this was a prospective cohort study, with pre-planned visits and scheduled sera collection, which allows precisely estimating incident SARS-CoV-2 infection and the outcome of COVID-19. Since prospective data on the incidence and risk of SARS-CoV-2 infection in PLWH are lacking [6], the present study fills part of this gap. These are the most important strengths of this study. In summary, the incidence of COVID-19 among PLWH in Seville, Southern Spain after three waves of COVID-19 pandemic was lower to that observed in the general population in the same geographical area. The severity of COVID-19 was similar to that in patients without HIV infection and determined by comorbidities and age. Nevertheless, some HIV-related factors, as historical immunosupp...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.03.20.21253397 on medRxiv