Genetic risk and incident venous thromboembolism in middle‐aged and older adults following COVID‐19 vaccination

  1. Junqing Xie
  2. Albert Prats‐Uribe
  3. Maria Gordillo‐Marañón
  4. Victoria Y. Strauss
  5. Dipender Gill
  6. Daniel Prieto‐Alhambra

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Abstract

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  1. Version published to 10.1111/jth.15879
  2. ScreenIT

    SciScore for 10.1101/2022.04.14.22273865: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: UKBB received ethical approval from the research ethics committee (National Health Service’s National Research Ethics Service North West (11/NW/0382), with all participants providing written consent.
    Consent: UKBB received ethical approval from the research ethics committee (National Health Service’s National Research Ethics Service North West (11/NW/0382), with all participants providing written consent.
    Field Sample Permit: This study was conducted under Application Number 65397.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power AnalysisTo ensure sufficient statistical power, this analysis was only performed in the 90-days follow-up window.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our analyses have some potential limitations. First, VTE often presents variable clinical manifestations with challenging differential diagnoses such as myocardial infarction and congestive heart failure.2 Consequently, identification of VTE in a real-world setting is likely subject to information bias, which typically drives risk estimates towards the null. Second, we were not able to generate a parallel unvaccinated comparison group because more than 99% of UKBB participants had been vaccinated. However, we constructed a historical comparison cohort with similar characteristics to those vaccinated. Also, given the relatively short follow-up after vaccination, the long-term impact of the genetic factor remains to be determined. Third, although we also constructed a secondary PRS for VTE, the weights of each included SNP have not been previously validated, and their utility in a PRS remains unknown. Opportunely, it conferred consistent results as the primary PRS did, likely due to the fact that both PRSs included the factor V Leiden p.R506Q and prothrombin G20210A variants which are known causes of inherited thrombophilia predisposing to acute thrombotic syndromes14,15. Fourth, the HR estimates for each vaccine type should be considered exploratory in nature due to evident differences in the baseline risk for VTE seen between people vaccinated with the two vaccines. Last, the generalizability of our findings should be tested in more diverse ethnic populations as more integrat...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2022.04.14.22273865v1 on medRxiv