Estimating the sensitivity of non-treponemal and treponemal antibody tests in primary syphilis
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Among patients with primary syphilis, sensitivity of TRUST was 55% (6/11) compared to darkfield microscopy (DFM) and 60% (9/15) compared to Treponema pallidum PCR. Sensitivity of RPR was 78% (38/49) and 93% (43/46), respectively. TPPA had a sensitivity of 95% (41/43) compared to DFM and 96% (43/45) compared to PCR.
Short Summary
Compared to direct detection methods for the diagnosis of primary syphilis, TRUST has low sensitivity, RPR has moderate to good sensitivity, and TPPA has high sensitivity.
