Structural basis for MurJ inhibition by phage lysis protein Sgl PP7 suggesting convergence
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Some bacteriophages encode lysis proteins that inhibit essential bacterial processes, the elucidation of which is valuable for developing antibacterial strategies against drug-resistant pathogens. We determined the cryo-EM structure of the complex between the essential E. coli lipid II flippase MurJ and a phage lysis protein, Sgl PP7 . MurJ was locked in an outward-facing conformation by Sgl PP7 , similar to the MurJ/Lys M complex; however, distinct interactions suggest convergent evolution among phage lysis proteins.
