Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis

Obesity, gastrointestinal disorders, and mental health conditions are major drivers of employer healthcare expenditures, yet nutrition-based interventions are rarely reimbursed by health insurance. Precision nutrition, which integrates genetic, gut microbiome, biometric, and behavioral data to guide personalized dietary and lifestyle changes, may provide a scalable approach to reducing costs associated with diet-responsive conditions. This retrospective cohort study analyzed medical claims from January 2022 to December 2024 across seven U.S. self-insured employers. Employees enrolled in a precision nutrition digital therapeutic (n = 258) were compared with non-enrolled peers (n = 8,268) using a two-stage difference-in-differences model with member and month fixed effects and clustered standard errors. Enrollment was associated with a reduction of –$3,012 per member per year ( PMPY; p = 0.021) in diet-responsive medical spending. The largest relative reductions were observed for digestive disorders ( –$9,240 PMPY; p = 0.029) and obesity ( –$4,884 PMPY; p = 0.007), with smaller effects for anxiety-related conditions ( –$1,356 PMPY; p = 0.043). Total medical spending decreased by –$4,044 PMPY but was not statistically significant (p = 0.09). These results suggest that precision nutrition digital therapeutics may reduce medical expenditures for diet-responsive conditions and represent a scalable strategy for employers to address the economic burden of chronic disease.