Topical application of a skin serum with Progerin inhibitor helps alleviate human skin aging

Skin aging is a complex process driven by intrinsic and extrinsic factors, resulting in structural and functional changes such as reduced elasticity, hydration loss, and the appearance of wrinkles. This study evaluates the efficacy and safety of a topical formulation with common skincare ingredients and a Progerin inhibitor, which is designed to combat multiple signs of skin aging.

A 4-week clinical trial was conducted with 21 female participants aged 30–50. The study measured key parameters of skin health, including crow’s feet wrinkle reduction, facial lifting improvement, skin hydration, elasticity, density, and tone brightness. Objective assessments, including dermatological evaluations and quantitative measurements, were complemented by subjective feedback from participants through efficacy and preference surveys.

The results demonstrated significant improvements across all evaluated parameters. After 4 weeks of use, participants exhibited a 5.631% reduction in wrinkles, a 3.234% improvement in facial lifting, an 18.435% increase in skin hydration, an 8.563% enhancement in elasticity, a 3.424% improvement in skin tone brightness, and a 23.583% increase in skin density (p < 0.05). No adverse reactions were reported, and the product was well-tolerated. Participant surveys further confirmed high levels of satisfaction with the skin serum’s performance and usability.

These findings indicate that the progerin inhibitor effectively improves multiple signs of skin aging, especially skin density increase, and supports its potential as a comprehensive anti-skin aging ingredient. This study contributes to advancing topical skincare formulations aimed at rejuvenating and maintaining healthy, youthful skin.

Research Objective

This study aimed to evaluate the effects of a skin serum containing a 1 % progerin inhibitor on eye wrinkles, facial lifting, skin moisturizing, skin elasticity, skin density, and skin tone brightness in women aged 30 to 55. The test was conducted by measuring the relevant test items before product use, and at 2 weeks and 4 weeks after use. After the trial was completed, effectiveness and preference surveys were conducted.