PolyGenie: An Interactive Platform for Visualising Polygenic Risk Across Multidimensional Cohorts

Polygenic risk scores (PRS) provide a quantitative measure of genetic predisposition to complex traits and diseases, and their predictive capacity has expanded significantly with the growth of large-scale genome-wide association studies (GWAS). Longitudinal population cohorts that integrate genomic, clinical, and lifestyle information offer a valuable setting for studying PRS-trait relationships across diverse phenotypic domains. However, accessible tools for systematic and interactive exploration of these associations remain scarce. Here, we present PolyGenie, a web-based platform designed for phenome-wide exploration of PRS associations with clinical diagnoses, metabolomic traits, lifestyle factors, and environmental exposures. The current implementation includes precomputed PRS for over 100 traits applied to 5,000 genotyped individuals from the GCAT cohort. Users can navigate interactive visualizations, including PheWAS-style association plots and disease prevalence trends across PRS percentiles, facilitating the interpretation of pleiotropic effects and population-level risk stratification. PolyGenie is freely accessible at https://polygenie.igtp.cat and aims to support hypothesis generation, biomarker discovery, and translational research in complex disease genetics.