OpTiles: An R Package for Adaptive Tiling and Methylation Variability Profiling
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Summary
OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG density with intra-region methylation variability, it provides a reliability metric and extended functionality for annotating, prioritizing, and interpreting complex methylation data.
Availability
OpTiles is implemented in R and source code is freely available at https://github.com/fhaive/OpTiles . Data are available on Zenodo at https://doi.org/10.5281/zenodo.16961293
Contact
dario.greco@tuni.fi
