Heart rate monitoring using wrist photoplethysmography in Parkinson disease: feasibility and relation with autonomic dysfunction
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Background
Cardiac autonomic dysfunction is a prevalent yet underdiagnosed non-motor manifestation in Parkinson disease (PD), and difficult to monitor in daily life. Wrist-worn photoplethysmography (PPG) allows for continuous pulse rate monitoring, with potential to measure cardiac autonomic dysfunction in PD. However, motion artifacts pose significant challenges. We propose a two-step approach to account for PPG motion artifacts, and explore the association between pulse rate characteristics and cardiac autonomic dysfunction in PD.
Methods
In 444 people with early PD, we used continuous wrist PPG and accelerometer data, collected during two weeks, with an average wear time of 22h/day. Step 1 filters low-quality segments based on PPG morphology using a logistic regression classifier. Step 2 removes remaining segments with periodic motion artifacts (e.g. introduced by tremor). Weekly aggregates were calculated for resting (day, night) and maximum (day) pulse rates. We studied the effect of filtering on the pulse rate estimates and assessed the relationship between pulse rate aggregates and both subjective and objective autonomic dysfunction measures.
Results
Median proportion of high-quality PPG data was 29.2% [IQR: 24.0% to 35.9%] during the day, and 86.1% [IQR: 79.3% to 90.6%] during the night. Proportions of high-quality PPG data were similar across different rest tremor severity and dyskinesia scores. However, filtering out periodic motion artifacts (step 2) reduced overestimation of the maximum HR in persons with mild or severe rest tremor. More symptoms of autonomic dysfunction were associated with a lower maximum pulse rate during the day (β:-0.17, 95% CI: [−0.33, −0.00]), while resting pulse rate showed no association. No significant differences in pulse rate metrics were found between individuals with or without orthostatic hypotension.
Conclusions
PPG-based heart rate estimation in PD improves when periodic motion artifacts are accommodated, representing an important step toward developing digital biomarkers of cardiac autonomic dysfunction. Maximum pulse rate in daily life only demonstrated a weak association with autonomic dysfunction, highlighting the need for more specific markers such as pulse rate variability.
Key contributions/strengths:
- Careful signal quality assessment, taking into account periodic artifacts by combining PPG and accelerometer
- Careful HR estimation using smoothed-pseudo Wigner-Ville, tested on an independent dataset.
- Evaluation on a unique large PPG dataset from people with PD
- Correlation to the clinical gold standard for autonomic dysfunction
- Pipeline open source available
