Protective Effects of Zingiber officinale Juice Extract Against Cisplatin-Induced Toxicity: Oxidative Stress, Biochemical, Hematological, And Reproductive Hormone Changes in Wistar Rats

Cisplatin, a widely used chemotherapeutic agent, is associated with significant toxicity. Zingiberofficinale , commonly known as ginger, has antioxidant and anti-inflammatory properties.The present study was conducted to investigate the protective effects of Zingiberofficinale juice against cisplatin-induced toxicity in Wistar rats.Rats were divided into control group, cisplatin induced (7 mg/kg), Zingiberofficinale juice (500 mg/kg), and combination groups. Biochemical, hematological, oxidative stress, inflammatory, and apoptotic markers were assessed using standard protocol.In this study, it was observed that Cisplatin administration significantly increased liver and kidney weights, altered biochemical parameters (ALT, AST, ALP, bilirubin, and creatinine), and induced oxidative stress (MDA), inflammation (TNF-α, IL-1β, IL-6), and apoptosis (caspase-3, Bax). In contrast, Zingiberofficinale juice supplementation significantly reduced liver and kidney weights, improved biochemical parameters, decreased oxidative stress and inflammatory markers, inhibited apoptotic markers, and enhanced antioxidant defenses (GSH, SOD, CAT). Notably, the combination of Zingiberofficinale juice and cisplatin showed improved biochemical, hematological, oxidative stress, inflammatory, and apoptotic markers compared to cisplatin alone, demonstrating the protective effects of Zingiberofficinale juice against cisplatin-induced toxicity. Zingiberofficinale juice exhibits protective effects against cisplatin-induced toxicity in Wistar rats, suggesting its potential as an adjunctive therapy to reduce chemotherapy-related side effects.