Prevalence and factors associated with use of prophylaxis for HIV and sexually transmitted infections among sexual health service attendees in England: findings from a cross-sectional observational study

  1. James Bell
  2. Manik Kohli
  3. Caisey Pulford
  4. Dana Ogaz
  5. Elizabeth Williams
  6. Vanessa Apea
  7. Nelson David
  8. Emmi Suonpera
  9. Richard Gilson
  10. Catherine H. Mercer
  11. Gwenda Hughes
  12. David Dunn
  13. Ed Showler
  14. Hamish Mohammed
  15. John Saunders
Read the full article See related articles

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

Introduction

HIV pre-exposure prophylaxis (PrEP) demonstrates the value of biomedical interventions as part of combination prevention. Some gay, bisexual and other men who have sex with men (GBMSM) use antibiotics to prevent sexually transmitted infections (STIs), primarily as post-exposure prophylaxis (PEP). We aimed to understand variations in awareness and use of HIV PrEP and STI PEP/PrEP among people attending specialist sexual health services (SHS) in England.

Methods

We collected data from SHS attendees aged >16 years in London and the East of England using an online questionnaire between April 2022 and December 2023, including awareness and use of HIV-PrEP and STI PEP/PrEP. We ran regression analyses: one to identify demographic factors associated with STI PEP/PrEP use among all SHS attendees, and a second to identify behavioural factors (controlling for socio-demographic factors) associated with antibiotic prophylaxis use among GBMSM.

Results

The study recruited 1,732 participants (50% GBMSM, 12% men who had reported sex with women only [MSW], 31% women). 74% had heard of HIV-PrEP but this varied by group (GBMSM:98%, MSW:39%, women:49%). 34% of GBMSM had heard of STI PEP/PrEP and 11% reported using it (MSW:15%/5%, women:18%/4%). 61% of STI PEP/PrEP users reported taking doxycycline, mostly to prevent chlamydia, gonorrhoea and syphilis. 80% of all participants reported being somewhat/very likely to use event-based STI PEP/PrEP, with a higher proportion of GBMSM saying they would be likely to use STI PEP/PrEP in this way. In the behavioural regression model of GBMSM, use was independently associated with reporting higher-risk sexual behaviour.

Conclusion

We found that a sizeable minority of GBMSM already use STI PEP/PrEP but some MSW and women also use or have an interest in antibiotic prophylaxis, suggesting potential benefits may exist for populations other than GBMSM. Communication should therefore should emphasise appropriate antibiotic use and the risks of antibiotic resistance among all populations.

Key messages

KWhat is already known on this topic

  • Despite widespread availability of HIV-PrEP, heterosexual men and women with a need for HIV-PrEP are less likely to have this met than GBMSM

  • Some GBMSM use antibiotics to prevent bacterial STI infections in the absence of guidelines on STI PEP/PrEP in England

What this study adds

  • Awareness of HIV-PrEP is low among heterosexual men and women

  • The study shows that some heterosexual men and women are currently using or have an interest in STI PEP/PrEP

How this study might affect research, practice or policy

  • This study could inform HIV-PrEP awareness activities for people at risk of HIV

  • It could also inform communication strategies for any future introduction of STI PEP/PrEP

Article activity feed

  1. Version published to 10.1101/2025.07.31.25332508 on medRxiv