Prevalence and characteristics of women with polycystic ovary syndrome and isolated diagnostic feature using the International evidence-based guideline and antimüllerian hormone: A nationwide cross-sectional survey
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Background
Previous studies reported polycystic ovary syndrome (PCOS) prevalence using consensus guidelines and ultrasonography. Data on stepwise decision-making by the International evidence-based guidelines and using anti-müllerian hormone (AMH) for prevalence were limited.
Objective
This nationwide cross-sectional survey determined the prevalence and characteristics of PCOS and isolated diagnostic features among reproductive-aged Bangladeshi women (10-45 years) using the International Evidence-based Guidelines, 2023, incorporating AMH.
Methods
Conducted April-September 2024 across eight divisions (one urban & one rural) of Bangladesh, 1201 females were sampled. Participants underwent fasting, OGTT, and detailed data collection (demographic, lifestyle, reproductive history, and physical measurements). Blood was analyzed for glucose, lipid, and ALT. Total testosterone (TT) was measured for isolated irregular cycles. Adults with only significant hirsutism or irregular cycles with normal testosterone levels were further evaluated by AMH. Thyroid dysfunction and hyperprolactinemia were excluded. TT and AMH cut-offs were derived from 100 hirsutism-free adult women with regular cycles.
Results
Of 1201 participants, 403 were excluded. Among 798 eligible women, 38 (4.8%) had both irregular cycles and significant hirsutism, 75 (9.4%) had only significant hirsutism, 141 (17.7%) had only irregular cycles, and 544 (68.2%) had neither. After TT and AMH evaluation and excluding two hyperprolactinemia cases, a 6.9% (55/798) prevalence was found among 57 women with probable PCOS. Familial predisposition, unhealthy sleep behaviour, and higher androgenic and metabolic features were observed in women with PCOS versus controls. Metabolic syndrome frequency was higher among adult PCOS (33.3% vs. 4.0%) than adolescent PCOS.
Conclusion
The community-based prevalence of PCOS among Bangladeshi women was 6.9%, with distinctive features compared to controls. Women with isolated diagnostic criteria require further evaluation and long-term follow-up.
Highlights
This study used a stepwise decision-making approach and antimüllerian hormone to determine the prevalence of polycystic ovary syndrome and isolated diagnostic features in a nationwide cross-sectional survey.
The estimated prevalence of PCOS was 6.9% among 798 reproductive-aged Bangladeshi women, consisting of 5.9% and 8.0% of adolescent and adult PCOS, respectively.
This study also identified 15.5% and 9.1% of women with isolated irregular cycles and significant hirsutism, respectively, who required further evaluation and follow-up.
