A comprehensive data repository of environmental toxicants exposed mouse epigenomes from the TaRGET II Consortium

The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) is a multiphase program that aims to understand how environmental factors contribute to disease susceptibility using toxicant-exposed mouse models. Here, we introduce the TaRGET II Data Portal ( https://data.targetepigenomics.org/ ), a repository of exposomes from mice exposed to environmental toxicants, including arsenic (As), lead (Pb), bisphenol A (BPA), tributyltin (TBT), di(2-ethylhexyl) phthalate (DEHP), tetrachlorodibenzo-p-dioxin (TCDD), and air pollution (PM2.5). Sequencing assays capturing changes in chromatin accessibility, DNA methylation, gene expression, and post-translational histone modifications from multiple centers were quality-controlled and uniformly processed. The datasets cover multiple tissues collected at four time points: 3 weeks, 5 weeks, 20 weeks, and 40 weeks. The TaRGET II Data Portal offers an efficient way to browse, search, visualize, and download relevant datasets and associated metadata, serving as a key resource for studying the impact of environmental toxicant exposures on disease susceptibility for the broader scientific community.