Evaluating Cardiometabolic Indices for Predicting Thrombotic Risk in the Indian Adult Population: A Comparative Analysis
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Background
Cardiometabolic indices are quick measures of visceral adipose dysfunction that bear significant association with risk of future thrombotic events. Traditionally, body mass index (BMI) and waist circumference (WC) have been used for screening large population masses. With the advent of novel indices with better predictive value, it is imperative to validate the utility of these indices in a demography-specific fashion.
Objective
In our study, we have attempted to identify the best-performing predictor and its optimal cut-off point specific to the Indian population.
Methods
Our study is a hospital-based cross-sectional study involving 200 participants visiting the master health check-up center of our tertiary-care institution. After clinical, anthropometric and biochemical assessments, twenty cardiometabolic indices were calculated for all the participants. Individual cardiovascular, stroke and thromboembolic risks were ascertained through Framingham Risk Score, CHA 2 DS 2 VASc score, and Padua Prediction Score, respectively. ROC analysis was done to identify the indices with statistically significant predictive association for thrombotic risk.
Results
In our study, eight indices (NVAI, METS-VF, ABSI, CI, WHR, CVAI, TyG-WC, CMI) have shown significant predictive potential for coronary risk, and eleven indices (RFM, BFP, NVAI, WHtR, BRI, TyG-index, CI, VAI, ABSI, TyG-WC, METS-IR) for stroke risk, while four indices (NVAI, ABSI, CI, TyG-WC) are predictive of both risks.
Conclusion
Overall, NVAI is the best predictor of future thrombovascular catastrophe for the Indian demography (FRS AUC = 0.769, CHA 2 DS 2 VASc AUC = 0.663; p-value < 0.05) with optimal cut-off point of 0.972 (males = 0.993, females = 0.913). BMI has shown poor predictive performance for thrombotic risk as compared to the other indices. Cardiometabolic indices, in general, have limited utility in prediction of future venous thromboembolic events.
