PrecisionPro Fusion: Clinical Validation of an Automated MRI-CT Fusion System for Prostate Radiotherapy Planning
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Background
Accurate image registration between magnetic resonance imaging (MRI) and computed tomography (CT) is required for precise radiation therapy of prostate cancer. Manual registration methods have been identified as a significant barrier to the implementation of advanced treatment techniques such as focal boost therapy.
Purpose
To evaluate the accuracy of PrecisionPro Fusion—an automated MRI-CT registration pipeline— compared to manual registration by experienced radiation oncologists.
Materials and Methods
We conducted a prospective, multi-institutional validation study involving six genitourinary radiation oncologists from three institutions who performed registrations on 20 patient cases. The study used a two-round design with a one-month washout period, where physicians conducted MRI-CT registrations with and without PrecisionPro Fusion. We compared PrecisionPro Fusion to practical accuracy limits of manual registration, defined by intra-physician variability (distance between a physician’s two MRI-CT registrations of the same patient case) and inter-physician variability (maximum distance between a physician’s registration and the physician consensus— average of all physicians’ registrations of that patient case). Physician participants reported on the PrecisionPro Fusion user experience using a System Usability Scale questionnaire.
Results
Intra-physician variability for manual subspecialist registrations was median 2.9 mm (IQR: 1.9, 5.4); inter-physician variability was median: 4.7 mm (4.3, 5.7). PrecisionPro Fusion registrations had median distance from the physician consensus of 1.3 mm (IQR: 0.9, 2.7). The system received high usability scores (median 81; IQR: 74, 88).
Conclusion
PrecisionPro Fusion provides prostate MRI-CT registration accuracy comparable to manual physician registration. Automated MRI-CT registration could enable faster delineation of structures visible on MRI, including the urethra and intraprostatic tumors.
