Wastewater Parvovirus B19 Signal Amid Rising Maternal Cases

  1. Justin R. Clark
  2. Michael J. Tisza
  3. Alexandra L. Hammerquist
  4. Harihara Prakash
  5. Jessian L. Munoz
  6. Anil Surathu
  7. Sara J. Javornik Cregeen
  8. Noah W. Parker
  9. Magdalena Sanz Cortes
  10. Blake Hanson
  11. Jennifer Deegan
  12. Eric Boerwinkle
  13. Enrico R. Barrozo
  14. Anthony W. Maresso
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Abstract

We report widespread detection of parvovirus B19 in Texas Wastewater using hybrid-capture virome sequencing across 43 sites. Wastewater signal correlated with clinical cases at institutional, county, and state levels and preceded case surges by one month. Full-genome coverage enabled real-time mutation tracking, highlighting wastewater’s utility for epidemiologic surveillance.

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  1. Version published to 10.1101/2025.07.07.25331044 on medRxiv