Homoeolog expression in polyploid wheat mutants shows limited transcriptional compensation
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Active transcriptional compensation between gene duplicates (paralogs or homoeologs) has been proposed to facilitate functional redundancy, whereby mutations in multiple gene copies are required before a phenotype is observed. We tested whether transcriptional compensation occurs between homoeologs in response to premature termination codon (PTC) mutations in mutagenised wheat lines. Only ∼3% of cases showed homoeologous upregulation in response to PTC mutations, suggesting that there is no widespread active transcriptional compensation between wheat homoeologs.
