A blinded, controlled randomized clinical trial on the efficacy of neck muscle vibration in patients with post-stroke neglect
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Background and Aim
Unilateral spatial neglect (UN) impairs patients’ ability to detect and respond to stimuli on the contralesional side, severely limiting functional recovery after right-hemispheric stroke. Neck muscle vibration (NMV) has been shown as a bottom-up, proprioceptive intervention to modulate spatial neglect. Although preliminary studies found promising effects, the isolated efficacy of NMV for neglect rehabilitation has not yet been tested in a randomized, blinded controlled trial. This study aimed to evaluate whether NMV alone improves neglect symptoms and activities of daily living.
Methods
Twenty patients with right-hemispheric stroke and UN were randomly assigned to receive either active or placebo NMV over two weeks (5 sessions/week). Both groups received 20-minute daily vibration sessions. Standard neglect therapy was withheld in the active group but administered in the placebo group. Assessments included standard neglect diagnostics (e.g., Letter Cancellation, Bells Test), the Free Exploration Test (FET), and two ADL-based measures (NET, CBS), conducted before, immediately after, and (for the NMV group) one month post-treatment.
Results
The active NMV group showed significant improvements in three of four standard neglect tests, exploration behavior (FET), and ADL performance, with effects remaining stable at one-month follow-up. The placebo group showed comparable gains in ADL outcomes but improved in one standard neglect test only. Between-group analyses revealed no statistically significant differences, suggesting similar efficacy of both interventions.
Conclusion
NMV alone yields clinically meaningful and lasting improvements in neglect symptoms and daily functioning, comparable to standard active exploration therapy. Its passive nature makes it a promising tool, especially for early rehabilitation.
