Cognitive behavioral therapy for insomnia as a suicide prevention strategy: a protocol for a systematic review and meta-analysis
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Background
Insomnia is a highly prevalent and debilitating sleep-wake disorder, with growing evidence indicating that it is an independent risk factor for suicidal ideation and behaviors. Cognitive behavioral therapy for insomnia (CBT-I) is the recommended first-line treatment for chronic insomnia. However, its effect on suicidal ideation and behaviors in those with insomnia has not been well-characterized. Thus, the aim of the planned meta-analysis is to quantify the effects of CBT-I on suicidal ideation, suicidal behaviors and suicide deaths in adults with insomnia with and without comorbidities.
Methods
The planned study will include randomized controlled trials (RCTs) comparing CBT-I with a control condition with no presumed strong effect on insomnia in individuals with insomnia according to standardized diagnostic criteria or a clinically relevant screening score. Both published and unpublished RCTs will be retrieved through a systematic search in major databases and trial registries. The primary outcomes include 1) suicidal ideation, 2) suicidal behaviors, and 3) suicide deaths, assessed post-treatment and at follow-ups. We will only consider RCTs reporting suicide-related outcomes and/or enrolling participants with suicidal ideation or behaviors. For continuous data, a random-effects meta-analysis will be conducted to estimate (standardized) mean differences. In the case of categorical data, a random-effects logistic regression meta-analysis model will be used. The risk of bias of the primary outcomes will be evaluated using the Cochrane Risk of Bias 2 tool. The certainty of evidence will be assessed using GRADE. All analyses will be conducted in the R software.
Discussion
The planned meta-analysis will provide a synthesis of the effects of CBT-I on suicide-related outcomes in individuals with insomnia. The findings could have important implications for integrating sleep-focused interventions into suicide prevention strategies and inform clinical practice, particularly for individuals with comorbid insomnia and increased suicide risk.
Systematic review registration
PROSPERO-ID CRD420250628820
Review question
How effective is cognitive behavioral therapy for insomnia (CBT-I) in reducing suicidal ideation, suicidal behaviors and suicide deaths among adults with insomnia with and without comorbidities?
