Visual Memory Performance Correlates with Alzheimer’s Disease Biomarkers in Cognitively Normal Individuals

Read the full article See related articles

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

INTRODUCTION

Alzheimer’s disease (AD) pathology evolves silently for many years prior to disease, and early identification of individuals at greatest risk is critical for improving outcomes.

METHODS

We conducted exploratory factor analysis (EFA) using neuropsychological testing from 1,697 healthy adults. Factor scores were submitted as predictors for structural MRI, functional connectivity, and cerebrospinal fluid (CSF) biomarkers.

RESULTS

The EFA model identified five latent factors. Factor 1, Verbal Memory, included high loadings from Rey Auditory Verbal Learning Test, and Factor 2, Visual Memory, included high loadings from Rey Complex Figure Test (RCFT). Factor 2 positively correlated with hippocampal volume, precuneus and posterior salience network connectivity, and negatively with CSF tau. Factor 1 correlated with hippocampal volume but not with network connectivity or CSF biomarkers.

DISCUSSION

Results demonstrate a significant relationship of visual memory with AD biomarkers. RCFT may be an important assessment for evaluating and tracking individuals during the earliest stages of Alzheimer’s pathology.

Article activity feed