Independent serum metabolomics approaches identify disrupted glutamic acid and serine metabolism in Parkinson’s disease patients
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Previous studies assessing blood metabolomic profiles in Parkinson’s disease (PD) patients showed inconsistent results. Here, we employed ¹H-NMR and UPLC/MS analyses on serum samples from a cohort of PD patients and healthy controls (HC). Compared to HC, PD patients showed: (i) higher glutamine, serine, pyruvate and lower α-ketoglutarate levels ( 1 H-NMR); (ii) higher glycine and lower glutamic acid concentrations (UPLC/MS). Several pathways associated with amino acids, mitochondrial and antioxidant metabolism emerged as dysregulated in PD. Our findings highlight a prominent disruption of cellular bioenergetic pathways and amino acid homeostasis in PD.
