Chronic suppurative otitis media: understanding its prevalence, bacterial spectrum, and antimicrobial resistance patterns among patients presenting with middle ear infections at KCMC in 2022, Tanzania: A hospital-based crosssectional study
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Background
The global incidence of chronic suppurative otitis media is as high as 4.76% i.e. 31million cases with 22.6% of these cases occurring in children under five years. With a prevalence of 30.82 per ten-thousand, each year 21 thousand people die due to complications of chronic suppurative otitis media.
Objective
the objective of this study was to determine the prevalence of chronic suppurative otitis media, its bacteriological profile, and antimicrobial susceptibility pattern among patients presenting with middle ear infections at KCMC, 2022.
Methodology
This hospital-based cross-sectional study was conducted at KCMC, ENT department from 15-03-2022 to 30-05-2022 and enrolled 201 participants by convenient sampling. From those confirmed with CSOM, a discharge swab was collected for microbiological investigations. Antimicrobial susceptibility was performed using the Modified Kirby-Bauer disk diffusion method. Data was analyzed using SPSS.
Results
Of 201 participants, 23 (11.4%) were confirmed to have CSOM. Prevalence of CSOM was higher at 22.4% (13/58) in children under five years of age. The proportion of CSOM infection was higher among males 12.9% (11/85) compared to females 10.3% (12/116). CSOM prevalence was high among rural participants 15.7% (17/108) compared to urban 6.4% (6/93). Out of 23 CSOM discharge swabs, 82.6% (19/23) were culture-positive. S. aureus was the most common isolate 28.57% (6/23). Most isolates were Multi-drug resistant with the highest drug resistance found against penicillin antibiotics (60%-70%), lower to medium resistance (11-50%) against Cefotaxime, Meropenem, Ciprofloxacin, Chloramphenicol, Ceftazidime, Erythromycin, and Cefoxitin. At the same time, there was no resistance to Amikacin.
Conclusion
The high prevalence of CSOM and a high proportion of MDR bacteria among CSOM patients is a threat to patient management. Continuing empirical treatment could escalate the problem. We highly recommend microbiological analysis of middle ear discharge to study bacterial profile and drug susceptibility for the provision of proper and effective antibiotic treatment to CSOM patients.
