Healthcare resource utilization and use of biologics in chronic spontaneous urticaria
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Importance
Biologic therapies have emerged as a promising treatment for chronic spontaneous urticaria (CSU), a debilitating skin disease. However, real-world data on their use is limited.
Objective
Analyze the time from diagnosis to biologic therapy initiation and the CSU-specific healthcare resource utilization (HCRU)
Design
Retrospective cohort study
Setting
Veterans Health Administration (VHA) from January 2011 through December 2021
Participants
Veterans ≥18 years of age with ≥2 urticaria diagnoses or one urticaria and one angioedema diagnosis with no diagnosis of urticarial vasculitis
Exposures
Diagnosis of CSU, defined as ≥2 urticaria diagnoses (ICD9 codes: 708.1, 708.8, 708.9; ICD10 codes: L50.1, L50.8, L50.9) or one urticaria and one angioedema (ICD9 code: 995.1; ICD10 code: T78.3) diagnosis
Main outcomes and measures
Time from diagnosis to biologic initiation and CSU-specific outpatient visits, inpatient admissions, emergency room visits, and pharmacy claims, in the 12-month pre- and post-index periods
Results
The final cohort included 26,387 Veterans with CSU, with a mean age of 54.9 years (SD=15.2). In the 12 month post-index period, 23,699 Veterans (89.8%) started treatment, but only 613 Veterans (2.6%) started biologic therapy, with a median initiation time of 337 days. CSU-specific HCRU increased notably in the post-index period across all categories. 66.8% of Veterans had pharmacy claims pre-index date compared to 89.8% post-index date. Outpatient visits were utilized by 92.4% of Veterans pre-index date and 96.7% post-index date.
Conclusion and relevance
The findings suggest that CSU management may be further optimized within the first year of diagnosis and that initiation of biologics may be considered sooner in appropriate patients. Additionally, the increased HCRU observed in the post-index period highlights the burden that CSU places on both patients and the healthcare system.
