Sustained Oropouche virus transmission in Rio de Janeiro’s Atlantic forest: genomic evidence over a two-year period

  1. Ighor Arantes
  2. Fernanda de Bruycker-Nogueira
  3. Carla de Oliveira
  4. Patrícia Carvalho Sequeira
  5. Otília Lupi
  6. Michele Borges
  7. Carolina Lopes Melo
  8. Michelle Brendolin
  9. Antonio Braga
  10. Luciane de Souza Velasque
  11. Andréa Cony Cavalcanti
  12. Adriana Cardoso Camargo
  13. Fábio Burack da Costa
  14. Cristiane Gomes de Castro Moreira
  15. Vanessa Zaquieu Dias
  16. Thiago de Jesus Sousa
  17. Felipe Donateli Gatti
  18. Gabriela Colombo de Mendonça
  19. Joana Zorzal Nodari
  20. Rodrigo Ribeiro-Rodrigues
  21. Edson Delatorre
  22. Guilherme Calvet
  23. Felipe Gomes Naveca
  24. Patricia Brasil
  25. Ana Maria Bispo de Filippis
  26. Gonzalo Bello
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Abstract

Since January 2024, over 1,500 Oropouche virus (OROV) cases have been confirmed in the Brazilian state of Rio de Janeiro. Genomic analyses showed that a lineage introduced in Rio de Janeiro in early 2024 persisted throughout 2025, highlighting the virus’s capacity for sustained transmission beyond the endemic Amazon region.

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  1. Version published to 10.1101/2025.05.28.25328307v2 on medRxiv
  2. Version published to 10.1101/2025.05.28.25328307v1 on medRxiv