Task-relevant cognitive maps in episodic memory

Cognitive maps support navigation by representing locations in internal spaces with Euclidean distances. Similar organizational principles may govern the representation of non-spatial sensory and conceptual features, enabling higher cognitive functions including decision making and model-based reinforcement learning. Previous studies have shown that medial temporal lobe (MTL) structures support the embedding of stimuli into cognitive maps. However, these studies investigated the generation of novel cognitive maps, while the recruitment of existing semantic knowledge into task-relevant representational spaces and their “remapping” according to changing goals has not been investigated. In addition, it is not clear how the MTL interacts with neocortical representations of task-relevant stimulus features and whether this influences the formation of novel episodic memory traces. Here we show that the neural representations of natural stimuli in both MTL and neocortex are organized in behaviorally relevant cognitive maps of conceptual features and influence the accessibility of novel memory traces. Cognitive maps organize information into internal spaces with Euclidean distances, adapt to ongoing task demands, and influence performance. Their representational structure matches neural similarities in the MTL, with a specific role of the hippocampus for task-dependent remapping. Further, we isolated task-relevant and stimulus-driven representations of natural stimuli and show how they contribute to the formation of memory traces. Together, our results suggest that conceptual representations are flexibly recruited in spatially organized cognitive maps of task-relevant features and that Euclidean distances in these cognitive maps affect subsequent memory.