Novel Highly Pathogenic Avian Influenza (A)H5N1 Triple Reassortant in Argentina, 2025

  1. Ralph E. T. Vanstreels
  2. Martha I. Nelson
  3. María C. Artuso
  4. Vanina D. Marchione
  5. Luana E. Piccini
  6. Estefania Benedetti
  7. Alvin Crespo-Bellido
  8. Agostina Pierdomenico
  9. Thorsten Wolff
  10. Marcela Uhart
  11. Agustina Rimondi
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Abstract

Genomic sequencing of re-emerging highly pathogenic avian influenza A(H5N1) virus detected in Argentina in February 2025 revealed novel triple-reassortant viruses containing gene segments from Eurasian H5N1 and low pathogenic viruses from South and North American lineages. These findings underscore continued evolution and diversification of clade 2.3.4.4b H5N1 in the Americas.

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  1. Version published to 10.1101/2025.05.23.655175v1 on bioRxiv