Troponin HsTnI as pronostic factor in Covid-19 patients : Mohammed VI Hospital University experience
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Background
Recent reports have demonstrated high troponin levels in patients affected with COVID-19.
We sought in our study to determine the relationship between troponin levels and COVID-19 outcomes severity/mortality.
Methods
This was an observational retrospective cohort study of 325 patients admitted and diagnosed COVID-19 positive in Mohammed VI CHU in Oujda from July 2021 to November 2021
Results
The mean age between deceased and cured patients (68.92 ± 15.06 vs 62.5 ± 15.73 years, respectively, p<0.001) but no significant difference in the sex ratio was found in the two groups (p 0.379).
191 on admission, had a measured troponin ≤26 whom 80.6% were hospitalized in covid unit, while 134 patients had a measured troponin > 26ng/ ml whom 56.5% were admitted in the ICU (p<0.001)
73% of patients with an admission troponin ≤26ng/L survived while 27% had deceased with p<0.001.Similarly, the measurement of serum Troponin at the of hospitalization was 73ng/L (25.6–319.6) while for discharged patients was 9.6 ng/L (4.3–31.7)
The distribution of hs-TnI maximum value measured, showed a concentration significantly higher in the deceased patients vs survivors [200 ng/L IQR 48–651 vs 19 ng/L IQR 7.97–85.87, p<0.001].
Conclusion
our study demonstrates that Troponin may be an indicator of severity and may contribute to determining the severity of patients infected with COVID-19. Utilising troponin measurements alongside with other clinical and laboratory variables can be used for identifying patients at higher risk of in-hospital mortality and there by predict the progression of COVID-19 towards a worse outcome and to assign for more stringent strategies of treatment
