Neighborhood deprivation moderates prognosis in behavioral-variant frontotemporal degeneration
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INTRODUCTION
Neighborhood deprivation has been associated with shorter survival, cognitive impairment and neurodegeneration in aging and Alzheimer’s disease. However, the association of neighborhood deprivation with disease progression in behavioral-variant frontotemporal degeneration (bvFTD) is unknown.
METHODS
We examined associations between tertiles of neighborhood deprivation, using the Area Deprivation Index (ADI), and survival in 311 individuals clinically diagnosed with bvFTD from the Penn Frontotemporal Degeneration (FTD) Center. In a subset of participants with complete baseline data across measures of global cognition, executive function, and language (n=163), we examined the association of ADI with longitudinal change.
RESULTS
Higher neighborhood deprivation was associated with shorter survival after symptom onset and faster decline in global cognition, executive and language functions, independent of genetic risk.
DISCUSSION
Living in more deprived neighborhoods (i.e. above the 50 th percentile nationally) was associated with an accelerated disease course in bvFTD, highlighting an important socioeconomic disparity in disease prognosis.
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