Unifying Orientation-Dependent Relaxation and Diffusion Around Axonal Fibers from DTI: Characterizing Fiber-Tract-Specific Anisotropic R ₂ Profiles of the Corpus Callosum

This work aims to characterize fiber-tract-specific orientation-dependent R ₂ from the seven callosal segments (CC1-CC7) based on human brain Connectome high-resolution DTI datasets. WM voxels from each segment were masked by the thresholds of FA and mode of anisotropy. Encoded in T2W images (b-value = 0), an orientation-dependent R ₂ profile was constructed based on voxel-wise fiber orientations and characterized by a “cone” model. This allowed , an orientation-dependent or anisotropic R ₂ , to be separated from its orientation-independent or isotropic counterpart. Except for , no discernible differences were found for the fits between the two b-values. On average, increased from 2.4±0.2 (1/s) to 3.2±0.3 (1/s) as the b-value increased. Furthermore, showed an increasing trend from CC1 to CC7 and the open angle α of the cone fluctuated around 65°. As usual, FA was found increasing from CC1 to CC7 and from a higher to a lower b-value. In conclusion, we have shown that fiber-tract-specific Anisotropic R ₂ profiles from the callosal segments can be characterized by a cone model. The proposed method offers a unique opportunity to reevaluate existing clinical DTI studies and optimize new ones for characterizing specific WM tracts in both healthy and diseased subjects.