GENETIC ENGINEERING THROUGH QUANTUM CIRCUITS: CONSTRUCTION OF CODES AND ANALYSIS OF GENETIC ELEMENTS BIOBLOQU
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The accelerated exploration and engineering of nucleotide sequences are directed towards quantum mechanics and their intrinsic entanglements, implementing the qubits states, including the development of algorithms. The production rate of biological sequencing data has increased to approximately 1 Gb/h, but the ability to analyse these data has not kept pace due to complexity issues and the limitations of classic computing. Despite its own challenges, quantum computing offers a potential solution for analysing biological data and extracting relevant information. Here, we developed and implemented a quantum algorithm that drives searches for genetic information. Our results demonstrated that two codes written based on quantum computing language could precisely search for a target sequence with 50 nucleotides in a DNA sequence database with up to 3022 nucleotides, building a synthetic structure called Quantum Biological Blocks (BioBloQu) inside a minimal JCVI-syn3.0 cells. Our algorithm constitutes a unique starting point for developing a more sophisticated model for the manipulation of data. This tool could be exploited for quantum-enhanced design, building synthetic genomes with desirable traits from the bottom up and exploiting genetic big data. Enhancing the algorithm and expanding device availability are significant targets for accelerating searches and gathering specific biodiversity features for research and applications.
