Assessment of Antibiotic Resistance and Associated Factors in Patients with Tuberculosis: A Nationwide Cross-Sectional Study of Indonesian TB-DRS
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Objective
Indonesia ranks second globally in terms of incidence of tuberculosis (TB), with a prevalence of 759 (95% CI: 589.7-960.8) cases per 100,000 people. Here, our cross-sectional population-based study (n=494) in Indonesia aims to reestablish the link between associated risk factors and antibiotic resistance.
Method
Data for this nationwide TB study was taken from the Tuberculosis Drug Resistance Survey (TB-DRS) by the Ministry of Health, Republic of Indonesia. The data was collected from a TB clinical field study conducted between 2017 and 2018. Participants provided demographic information through a self-report questionnaire after giving informed consent. Clinical samples were sent to our National Laboratory for testing the TB drug resistance status using MGIT960, GeneXpert, and Illumina-based WGS. Descriptive statistics were used to analyze the data with DATAtab software including Chi-square and other tests, and logistic regression. A significance level of p<0.05 was applied.
Results
TB resistance to drugs can be acquired irrespective of age-group (χ2=2.17, p=0.825), college education (OR: 1.1, 95% CI: 0.76-1.60, p=0.617, χ2=0.25), employment (OR: 0.93, 95% CI: 0.65-1.34, p=0.712, χ2=0.14), actively smoking (OR: 1.02, 95% CI: 0.61-1.69, p=0.951, χ2=0.00), geographical location (χ2=0.23, p=0.893), living community (OR: 0.94, 95% CI: 0.65-1.35, p=0.735, χ2=0.11), or previous attempts to seek treatment (OR: 1.26, 95% CI: 0.84-1.89, p=0.268, χ2=1.23). However, being female (OR: 1.6, 95% CI: 1.09-2.33, p=0.015, χ2=5.87), having a history of smoking (OR: 0.65, 95% CI: 0.45-0.94, p=0.021, χ2=5.36), and previously treated TB (OR: 0.02, 95% CI: 0.01-0.08, p<0.001, χ2=86.61) were linked to higher antibiotic resistance.
Conclusion
Focusing surveillance efforts on these statistically significant associated risk factors is crucial to halt the proliferation of drug-resistant TB within the population.
